Sam joins MediSieve following nearly six years at Pathios Therapeutics, where he worked across clinical operations, programme delivery and business development within the Molecule to Medicine biotech ecosystem. During his time at Pathios, Sam spent an extended secondment in Australia helping to deliver the company's first-in-human clinical programme for PTT-4256, including managing clinical operations on the ground and working closely with clinical sites and external partners. Sam studied at UCL, where his research included work on superhydrophobic surfaces and materials. At MediSieve, Sam will help coordinate technical programmes, external collaborations and operational delivery as the company advances its Magnetic Blood Filtration platform and application-specific development programmes.

About MediSieve  

MediSieve is a London-based start-up developing Magnetic Blood Filtration, a platform designed to selectively remove clinically relevant targets from the bloodstream. The technology combines target-specific therapeutic Magnetic Beads with an extracorporeal Capture System. During treatment, the Magnetic Beads are introduced into the extracorporeal blood circuit, where they mix with the patient’s blood and bind to their targets. The Capture System then magnetically removes the Beads and bound targets before the blood is returned to the patient. 

MediSieve’s lead application is focused on depleting anti-AAV neutralising antibodies (NAbs), which can exclude patients from receiving life-changing AAV gene therapy and prevent redosing. By removing anti-AAV NAbs prior to AAV administration, MediSieve aims to expand patient eligibility and create a potential pathway to future redosing. 

Beyond AAV gene therapy, Magnetic Blood Filtration is being developed as a broader platform that can be adapted to remove other clinically relevant circulating targets, either as a direct therapeutic approach or to enable other treatments. MediSieve is a spin-out from University College London and develops its technology in the White City Innovation District in West London.